Background:
@EN Atopic dermatitis(AD) exibit multiple immune abnormalities including elevated serum IgE levels and impaired cell mediated immunity, but basic immunologic defect is largely unknown.
@ES Objective:
@EN The purpose of this study was to evaluate the immunologic changes after treatment with Cyclosporin A(CsA) in AD patients.
@ES Methods:
@EN Eight patients of severe AD were treated with CsA(4mg/kg body weight per day) for 5 weeks, and evaluated clinical and immunological parameters before and after treatment.
@ES Peripheral blood eosinophil counts were significantly decreased after treatment(P<0.05), and serum IgE level was decreased but not significantly. In immediate hypersensitivity reaction by pinprick test, antigen score was significantly
decreased, and
in the evaluation of cell mediated immunity to recall antigens, total induration score was significantly increased(P<0.05). The number of helper T cell and helper/suppressor T cell ratio in peripheral blood, and the number of helper T and
suppressor T
cell in skin lesion were both significantly decreased after treatment(P<0.05). Clinical state after treatment was good in all of patients.
@ES Conclusion:
@EN The results indicate that CsA act on peripheral blood eosinophil and immediate and delayed hypersensitivity reaction as well as helper T-cells in peripheral blood and skin lesion, and it may by useful in the treatment of severe AD. (Kor J
Dermatol
1993 ; 31(2):210-216)
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